NRXN1 Antibody
Product Sizes
50ul
£316.00
OACA09146-50UL
100ul
£387.00
OACA09146-100UL
About this Product
- SKU:
- OACA09146
- Additional Names:
- Hs.22998;neurexin I;Neurexin I-alpha;neurexin-1;Neurexin-1-alpha;PTHSL2;SCZD17.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Cell surface protein involved in cell-cell-interactions; exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise; alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors; a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members; CBLN1 or CBLN2. In vitro; triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
- Gene Details:
- neurexin 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Neurexin-1 protein (31-310AA)
- Isotype:
- IgG
- Protein Details:
- Neurexin-1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
