IL36A Antibody
Product Sizes
50ul
£316.00
OACA08772-50UL
100ul
£387.00
OACA08772-100UL
About this Product
- SKU:
- OACA08772
- Additional Names:
- FIL1;FIL1 epsilon;FIL1(EPSILON);FIL1E;IL-1 epsilon;IL1(EPSILON);IL1F6;IL-1F6;IL-1F6 (FIL-1-epsilon);interleukin 1 family; member 6 (epsilon);interleukin-1 epsilon;interleukin-1 family member 6;interleukin-36 alpha.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes; dendritic cells and indirectly on T-cells to drive tissue infiltration; cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage; T-cell; and neutrophil chemokines; such as CCL3; CCL4; CCL5; CCL2; CCL17; CCL22; CL20; CCL5; CCL2; CCL17; CCL22; CXCL8; CCL20 and CXCL1; and the production of proinflammatory cytokines such as TNF-alpha; IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A; IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83; CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.
- Gene Details:
- interleukin 36 alpha
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Interleukin-36 alpha protein (1-158AA)
- Isotype:
- IgG
- Protein Details:
- Interleukin-36 alpha
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
