DDX11 Antibody
Product Sizes
50ul
£316.00
OACA08683-50UL
100ul
£387.00
OACA08683-100UL
About this Product
- SKU:
- OACA08683
- Additional Names:
- ATP-dependent DNA helicase DDX11;CHL1;CHL1-like helicase homolog;CHL1-related helicase gene-1;CHL1-related protein 1;CHLR1;DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog; S. cerevisiae);DEAD/H box protein 11;DEAD/H-box protein 11;hCHLR1;keratinocyte growth factor-regulated gene 2 protein;KRG2;KRG-2;probable ATP-dependent DNA helicase DDX11;probable ATP-dependent RNA helicase DDX11;WABS.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability; including DNA replication; DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783; PubMed:21854770; PubMed:23797032; PubMed:26089203; PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658; PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp; which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication; repair and homologous recombination reactions; including forked duplex; anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414; PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression; and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772; PubMed:18499658; PubMed:20124417; PubMed:23116066; PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR; which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641; PubMed:18499658; PubMed:22102414).
- Gene Details:
- DEAD/H-box helicase 11
- Host:
- Rabbit
- Immunogen:
- Recombinant Human ATP-dependent DNA helicase DDX11 protein (1-220AA)
- Isotype:
- IgG
- Protein Details:
- ATP-dependent DNA helicase DDX11
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
