H2AFY Antibody
Product Sizes
50ul
£316.00
OACA08608-50UL
100ul
£387.00
OACA08608-100UL
About this Product
- SKU:
- OACA08608
- Additional Names:
- core histone macro-H2A.1;H2A histone family member Y;H2A.y;H2A/y;H2AF12M;H2AFY;histone H2A.y;histone macroH2A1;histone macroH2A1.1;histone macroH2A1.2;MACROH2A1.1;macroH2A1.2;medulloblastoma antigen MU-MB-50.205;mH2A1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888; PubMed:15621527; PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors; including NF-kappa-B; and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888; PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs; which induces a hypoacetylated state of chromatin (PubMed:16428466; PubMed:16107708).
- Gene Details:
- macroH2A.1 histone
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Core histone macro-H2A.1 protein (123-372AA)
- Isotype:
- IgG
- Protein Details:
- Core histone macro-H2A.1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
