RNF34 Antibody
Product Sizes
50ul
£316.00
OACA08567-50UL
100ul
£387.00
OACA08567-100UL
About this Product
- SKU:
- OACA08567
- Additional Names:
- CARP1;CARP-1;caspase regulator CARP1;caspases-8 and -10-associated RING finger protein 1;E3 ubiquitin-protein ligase RNF34;FYVE-RING finger protein MOMO;hRFI;human RING finger homologous to inhibitor of apoptosis protein;RFI;RIF;RIFF;RING finger protein 34;ring finger protein 34; E3 ubiquitin protein ligase;RING finger protein RIFF;RING-type E3 ubiquitin transferase RNF34.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10; promoting their proteasomal degradation; to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly; may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity; through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).
- Gene Details:
- ring finger protein 34
- Host:
- Rabbit
- Immunogen:
- Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)
- Isotype:
- IgG
- Protein Details:
- E3 ubiquitin-protein ligase RNF34
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
