CALCOCO2 Antibody
Product Sizes
50ul
£316.00
OACA08298-50UL
100ul
£387.00
OACA08298-100UL
About this Product
- SKU:
- OACA08298
- Additional Names:
- antigen nuclear dot 52 kDa protein;calcium-binding and coiled-coil domain-containing protein 2;NDP52;nuclear domain 10 protein 52;nuclear domain 10 protein NDP52;nuclear dot protein 52.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382; PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A; MAP1LC3B and/or GABARAPL2; whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382; PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
- Gene Details:
- calcium binding and coiled-coil domain 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)
- Isotype:
- IgG
- Protein Details:
- Calcium-binding and coiled-coil domain-containing protein 2
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
