ISCU Antibody
Product Sizes
50ul
£316.00
OACA08123-50UL
100ul
£387.00
OACA08123-100UL
About this Product
- SKU:
- OACA08123
- Additional Names:
- 2310020H20Rik;HML;hnifU;iron-sulfur cluster assembly enzyme ISCU; mitochondrial;IscU iron-sulfur cluster scaffold homolog;ISU2;NIFU;nifU-like N-terminal domain-containing protein;NifU-like protein;NIFUN.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria; which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First; a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step; the cluster is released from ISCU; transferred to a glutaredoxin GLRX5; followed by the formation of mitochondrial [2Fe-2S] proteins; the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11; which serves as the sulfur donor for cluster synthesis; the iron-binding protein frataxin as the putative iron donor; and the electron transfer chain comprised of ferredoxin reductase and ferredoxin; which receive their electrons from NADH (By similarity).
- Gene Details:
- iron-sulfur cluster assembly enzyme
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Iron-sulfur cluster assembly enzyme ISCU; mitochondrial protein (1-167AA)
- Isotype:
- IgG
- Protein Details:
- Iron-sulfur cluster assembly enzyme ISCU; mitochondrial
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
