C8ORF4 Antibody
Product Sizes
50ul
£316.00
OACA07916-50UL
100ul
£387.00
OACA07916-100UL
About this Product
- SKU:
- OACA07916
- Additional Names:
- C8orf4;human thyroid cancer 1;protein C8orf4;TC1;TC-1;thyroid cancer protein 1;transcriptional and immune response regulator.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Seems to be involved in the regulation of cell growth an differentiation; may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001; PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway; positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells; enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response; seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer; it has been described as promoter of cell proliferation; G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392; PubMed:24941347). However; it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
- Gene Details:
- transcriptional and immune response regulator
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Transcriptional and immune response regulator protein (1-106AA)
- Isotype:
- IgG
- Protein Details:
- Transcriptional and immune response regulator
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
