ALOXE3 Antibody
Product Sizes
50ul
£316.00
OACA07362-50UL
100ul
£387.00
OACA07362-100UL
About this Product
- SKU:
- OACA07362
- Additional Names:
- ARCI3;E-LOX;eLOX3;eLOX-3;e-LOX-3;epidermal lipoxygenase;Epidermal lipoxygenase-3;epidermal LOX-3;epidermis-type lipoxygenase 3;hydroperoxide isomerase ALOXE3;hydroperoxy dehydratase ALOXE3;hydroperoxy icosatetraenoate dehydratase;hydroperoxy icosatetraenoate isomerase.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides; derived from arachidonic and linoleic acid by ALOX12B; into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen; oxygenates polyunsaturated fatty acids; including arachidonic acid; to produce fatty acid hydroperoxides. In the skin; acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative; a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel; it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord; it may regulate inflammatory tactile allodynia.
- Gene Details:
- arachidonate lipoxygenase 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
- Isotype:
- IgG
- Protein Details:
- Hydroperoxide isomerase ALOXE3
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
