APBB1 Antibody
Product Sizes
50ul
£316.00
OACA07361-50UL
100ul
£387.00
OACA07361-100UL
About this Product
- SKU:
- OACA07361
- Additional Names:
- adaptor protein FE65a2;amyloid beta (A4) precursor protein-binding; family B; member 1 (Fe65);amyloid-beta A4 precursor protein-binding family B member 1;FE65;MGC:9072;Protein Fe65;RIR;stat-like protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs); recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60; probably explains its transcription activation activity. Function in association with TSHZ3; SET and HDAC factors as a transcriptional repressor; that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
- Gene Details:
- amyloid beta precursor protein binding family B member 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)
- Isotype:
- IgG
- Protein Details:
- Amyloid-beta A4 precursor protein-binding family B member 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
