PVR Antibody
Product Sizes
50ul
£316.00
OACA07252-50UL
100ul
£387.00
OACA07252-100UL
About this Product
- SKU:
- OACA07252
- Additional Names:
- CD155;HVED;Necl-5;NECL5;nectin-like protein 5;poliovirus receptor;PVS;TAGE4.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site; leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange; and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR; and may trigger fratricide NK cell activation; providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
- Gene Details:
- PVR cell adhesion molecule
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Poliovirus receptor protein (220-345AA)
- Isotype:
- IgG
- Protein Details:
- Poliovirus receptor
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
