CUL4B Antibody
Product Sizes
50ul
£316.00
OACA07138-50UL
100ul
£387.00
OACA07138-100UL
About this Product
- SKU:
- OACA07138
- Additional Names:
- CUL-4B;cullin-4B;MRXHF2;MRXS15;MRXSC;SFM2.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein; contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1; histone H2A; histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E; and consequently; normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth; size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
- Gene Details:
- cullin 4B
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Cullin-4B protein (1-200AA)
- Isotype:
- IgG
- Protein Details:
- Cullin-4B
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
