CD4 Antibody
Product Sizes
100 ul
OACA07134-100UL
50 ul
OACA07134-50UL
About this Product
- SKU:
- OACA07134
- Additional Names:
- CD4 antigen (p55);CD4 receptor;CD4mut;IMD79;OKT4D;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4.|CD4 molecule
- Application:
- ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Formulation:
- Liquid
- Host:
- Rabbit
- Immunogen:
- Recombinant Human T-cell surface glycoprotein CD4 protein (26-396AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php