FAP Antibody
Product Sizes
50ul
£316.00
OACA06849-50UL
100ul
£387.00
OACA06849-100UL
About this Product
- SKU:
- OACA06849
- Additional Names:
- 170 kDa melanoma membrane-bound gelatinase;dipeptidyl peptidase FAP;DPPIV;FAPA;FAPalpha;Fibroblast activation protein alpha;gelatine degradation protease FAP;integral membrane serine protease;post-proline cleaving enzyme;prolyl endopeptidase FAP;seprase;Serine integral membrane protease;SIMP;surface-expressed protease.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- Varies by lot. See vial for concentration.
- Extra Details:
- Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling; fibrosis; wound healing; inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity; with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences; on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930; PubMed:16223769; PubMed:16480718; PubMed:16410248; PubMed:17381073; PubMed:18095711; PubMed:21288888; PubMed:24371721). Degrade also gelatin; heat-denatured type I collagen; but not native collagen type I and IV; vibronectin; tenascin; laminin; fibronectin; fibrin or casein (PubMed:9065413; PubMed:2172980; PubMed:7923219; PubMed:10347120; PubMed:10455171; PubMed:12376466; PubMed:16223769; PubMed:16651416; PubMed:18095711). Have also dipeptidyl peptidase activity; exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline; with a preference for Ala-Pro; Ile-Pro; Gly-Pro; Arg-Pro and Pro-Pro (PubMed:10347120; PubMed:10593948; PubMed:16175601; PubMed:16223769; PubMed:16651416; PubMed:16410248; PubMed:17381073; PubMed:21314817; PubMed:24371721; PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY); peptide YY (PYY); substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form; in association with either DPP4; PLAUR or integrins; is involved in the pericellular proteolysis of the extracellular matrix (ECM); and hence promotes cell adhesion; migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis; collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
- Gene Details:
- fibroblast activation protein alpha
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Prolyl endopeptidase FAP protein (26-280AA)
- Isotype:
- IgG
- Protein Details:
- Prolyl endopeptidase FAP
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
