ARG2 Antibody
Product Sizes
50ul
£316.00
OACA06838-50UL
100ul
£387.00
OACA06838-100UL
About this Product
- SKU:
- OACA06838
- Additional Names:
- arginase II;arginase; type II;arginase-2; mitochondrial;kidney arginase;kidney-type arginase;L-arginine amidinohydrolase;L-arginine ureahydrolase;nonhepatic arginase;non-hepatic arginase;type II arginase.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling; which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle; the clitoral corpus cavernosum and the vagina; arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).
- Gene Details:
- arginase 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Arginase-2; mitochondrial protein (1-354AA)
- Isotype:
- IgG
- Protein Details:
- Arginase-2; mitochondrial
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
