ACTL6B Antibody
Product Sizes
50ul
£316.00
OACA06769-50UL
100ul
£387.00
OACA06769-100UL
About this Product
- SKU:
- OACA06769
- Additional Names:
- 53 kDa BRG1-associated factor B;actin-like protein 6B;actin-related protein Baf53b;ACTL6;arpNalpha;BAF53B;BRG1-associated factor 53B;DEE76;EIEE76;hArpN alpha;IDDSSAD;SMARCN2.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities; changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex); as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion; and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons; npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A; are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).
- Gene Details:
- actin like 6B
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Actin-like protein 6B protein (1-280AA)
- Isotype:
- IgG
- Protein Details:
- Actin-like protein 6B
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
