TDG Antibody
Product Sizes
50ul
£316.00
OACA06692-50UL
100ul
£387.00
OACA06692-100UL
About this Product
- SKU:
- OACA06692
- Additional Names:
- G/T mismatch-specific thymine DNA glycosylase;hTDG;Thymine-DNA glycosylase.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model; involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes; hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T; it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
- Gene Details:
- thymine DNA glycosylase
- Host:
- Rabbit
- Immunogen:
- Recombinant Human G/T mismatch-specific thymine DNA glycosylase protein (141-410AA)
- Isotype:
- IgG
- Protein Details:
- G/T mismatch-specific thymine DNA glycosylase
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
