ALKBH1 Antibody
Product Sizes
50ul
£316.00
OACA06688-50UL
100ul
£387.00
OACA06688-100UL
About this Product
- SKU:
- OACA06688
- Additional Names:
- ABH;ABH1;alkB;alkB; alkylation repair homolog 1;ALKBH;alkylated DNA repair protein alkB homolog 1;alkylation repair; alkB homolog;alpha-ketoglutarate-dependent dioxygenase ABH1;DNA 6mA demethylase;DNA demethylase ALKBH1;DNA lyase ABH1;DNA N6-methyl adenine demethylase;DNA N6-methyl adenine demethylase ALKBH1;DNA oxidative demethylase ALKBH1;hABH;mRNA N(3)-methylcytidine demethylase;nucleic acid dioxygenase ALKBH1;tRNA N1-methyl adenine demethylase.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Dioxygenase that acts as on nucleic acids; such as DNA and tRNA (PubMed:18603530; PubMed:27745969; PubMed:27497299). Requires molecular oxygen; alpha-ketoglutarate and iron (PubMed:18603530; PubMed:27497299). A number of activities have been described for this dioxygenase; but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969; PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs; with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation; by mediating demethylation of tRNA(Met); and translation elongation; N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion; specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon; expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation; but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites; with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401; PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity).
- Gene Details:
- alkB homolog 1; histone H2A dioxygenase
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Alkylated DNA repair protein alkB homolog 1 protein (110-389AA)
- Isotype:
- IgG
- Protein Details:
- Nucleic acid dioxygenase ALKBH1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
