NONO Antibody
Product Sizes
50ul
£316.00
OACA06685-50UL
100ul
£387.00
OACA06685-100UL
About this Product
- SKU:
- OACA06685
- Additional Names:
- 54 kDa nuclear RNA- and DNA-binding protein;55 kDa nuclear protein;DNA-binding p52/p100 complex; 52 kDa subunit;MRXS34;NMT55;non-POU domain-containing octamer (ATGCAAAT) binding protein;non-POU domain-containing octamer-binding protein;NRB54;P54;p54(nrb);P54NRB;PPP1R114;protein phosphatase 1; regulatory subunit 114.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- DNA- and RNA binding protein; involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing; probably as a heterodimer with SFPQ. Interacts with U5 snRNA; probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1; required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro; the complex strongly stimulates DNA end joining; binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure; through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex; a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
- Gene Details:
- non-POU domain containing octamer binding
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Non-POU domain-containing octamer-binding protein (1-300AA)
- Isotype:
- IgG
- Protein Details:
- Non-POU domain-containing octamer-binding protein
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
