SPRTN Antibody
Product Sizes
50ug
£305.00
OACA05994-50UG
100ug
£463.00
OACA05994-100UG
About this Product
- SKU:
- OACA05994
- Additional Names:
- C1orf124;DNA damage protein targeting VCP;DNA damage-targeting VCP (p97) adaptor;DNA-dependent metalloprotease SPRTN;DVC1;PRO4323;Protein with SprT-like domain at the N terminus;spartan;zinc finger RAD18 domain-containing protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18; the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination; promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage; possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
- Gene Details:
- SprT-like N-terminal domain
- Host:
- Rabbit
- Immunogen:
- Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)
- Isotype:
- IgG
- Protein Details:
- SprT-like domain-containing protein Spartan
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
