CD177 Antibody
Product Sizes
50ug
£305.00
OACA05774-50UG
100ug
£463.00
OACA05774-100UG
About this Product
- SKU:
- OACA05774
- Additional Names:
- CD177 antigen;cell surface receptor;HNA-2a;HNA2A;human neutrophil alloantigen 2a;NB1;NB1 glycoprotein;NB1 GP;polycythemia rubra vera protein 1;PRV1;PRV-1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18; mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition; by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However; appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676; PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface; may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
- Gene Details:
- CD177 molecule
- Host:
- Rabbit
- Immunogen:
- Recombinant Human CD177 antigen protein (22-321AA)
- Isotype:
- IgG
- Protein Details:
- CD177 antigen
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
