RFX6 Antibody
Product Sizes
50ug
£305.00
OACA05292-50UG
100ug
£463.00
OACA05292-100UG
About this Product
- SKU:
- OACA05292
- Additional Names:
- dJ955L16.1;DNA-binding protein RFX6;MTCHRS;MTFS;Regulatory factor X 6;regulatory factor X domain-containing protein 1;regulatory factor X; 6;RFXDC1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032; PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function; thereby restricting the expression of the beta-cell differentiation and specification genes; and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).
- Gene Details:
- regulatory factor X6
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DNA-binding protein RFX6 protein (1-260AA)
- Isotype:
- IgG
- Protein Details:
- DNA-binding protein RFX6
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
