ACKR1 Antibody
Product Sizes
50ug
£305.00
OACA04814-50UG
100ug
£463.00
OACA04814-100UG
About this Product
- SKU:
- OACA04814
- Additional Names:
- atypical chemokine receptor 1;CCBP1;CD234;DARC;DARC/ACKR1;Dfy;Duffy antigen chemokine receptor;Duffy antigen/chemokine receptor;Duffy blood group antigen;Duffy blood group system protein;Duffy blood group; chemokine receptor;FY;Fy glycoprotein;glycoprotein D;GPD;GpFy;plasmodium vivax receptor;WBCQ1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile; interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2; CCL5; CCL7; CCL11; CCL13; CCL14; CCL17; CXCL5; CXCL6; IL8/CXCL8; CXCL11; GRO; RANTES; MCP-1; TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and; consequently; leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells; it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes; serves as blood reservoir of cognate chemokines but also as a chemokine sink; buffering potential surges in plasma chemokine levels.
- Gene Details:
- atypical chemokine receptor 1 (Duffy blood group)
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
- Isotype:
- IgG
- Protein Details:
- Atypical chemokine receptor 1
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
