BATF Antibody
Product Sizes
50ug
£305.00
OACA04748-50UG
100ug
£463.00
OACA04748-100UG
About this Product
- SKU:
- OACA04748
- Additional Names:
- activating transcription factor B;basic leucine zipper transcription factor; ATF-like;basic leucine zipper transcriptional factor ATF-like;B-ATF;BATF1;B-cell-activating transcription factor;SFA2;SFA-2;SF-HT-activated gene 2 protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17); follicular T-helper cells (TfH); CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells; leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'); an immune-specific regulatory element; followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells; involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection; can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage; part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3; leading to differentiation of HSCs; thereby restricting self-renewal of HSCs (By similarity).
- Gene Details:
- basic leucine zipper ATF-like transcription factor
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)
- Isotype:
- IgG
- Protein Details:
- Basic leucine zipper transcriptional factor ATF-like
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
