SRSF10 Antibody
Product Sizes
50ug
£305.00
OACA04643-50UG
100ug
£463.00
OACA04643-100UG
About this Product
- SKU:
- OACA04643
- Additional Names:
- 40 kDa SR-repressor protein;FUS interacting protein (serine-arginine rich) 1;FUS-interacting protein (serine-arginine rich) 2;FUS-interacting serine-arginine-rich protein 1;FUSIP1;FUSIP2;neural-salient SR protein;NSSR;PPP1R149;protein phosphatase 1; regulatory subunit 149;serine/arginine-rich splicing factor 10;serine-arginine repressor protein (40 kDa);SFRS13;SFRS13A;splicing factor SRp38;splicing factor; arginine/serine-rich 13;splicing factor; arginine/serine-rich 13A;SR splicing factor 10;SRp38;SRrp40;TASR;TASR1;TASR2;TLS-associated protein TASR;TLS-associated protein with Ser-Arg repeats;TLS-associated protein with SR repeats;TLS-associated serine-arginine protein;TLS-associated serine-arginine protein 1;TLS-associated serine-arginine protein 2;TLS-associated SR protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676; PubMed:12419250; PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1; a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs; prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions; leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons; with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).
- Gene Details:
- serine and arginine rich splicing factor 10
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA)
- Isotype:
- IgG
- Protein Details:
- Serine/arginine-rich splicing factor 10
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
