UBE2V1 Antibody
Product Sizes
50ug
£305.00
OACA03908-50UG
100ug
£463.00
OACA03908-100UG
About this Product
- SKU:
- OACA03908
- Additional Names:
- CIR1;CROC1;CROC-1;CROC1B;CROC-1B;DNA-binding protein;KUA-UEV;TMEM189-UBE2V1;TMEM189-UBE2V1 fusion protein;TMEM189-UBE2V1 readthrough transcript;TRAF6-regulated IKK activator 1 beta Uev1A;transmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through;UBE2V;ubiquitin-conjugating enzyme E2 variant 1;UEV1;UEV-1;UEV1A.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B; TNF; TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
- Gene Details:
- PEDS1-UBE2V1 readthrough|ubiquitin conjugating enzyme E2 V1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ubiquitin-conjugating enzyme E2 variant 1 protein (2-147AA)
- Isotype:
- IgG
- Protein Details:
- Ubiquitin-conjugating enzyme E2 variant 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
