CENPX Antibody
Product Sizes
50ug
£305.00
OACA03738-50UG
100ug
£463.00
OACA03738-100UG
About this Product
- SKU:
- OACA03738
- Additional Names:
- CENP-X;centromere protein X;D9;FAAP10;FANCM associated histone fold protein 2;FANCM-associated histone fold protein 2;FANCM-interacting histone fold protein 2;Fanconi anemia-associated polypeptide of 10 kDa;MHF2;retinoic acid-inducible gene D9 protein homolog;stimulated by retinoic acid 13 homolog;stimulated by retinoic acid gene 13 protein homolog;STRA13.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway; leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage; cellular resistance to DNA cross-linking drugs; and prevention of chromosomal breakage (PubMed:20347428; PubMed:20347429). In complex with CENPS (MHF heterodimer); crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins); rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428; PubMed:20347429). In complex with CENPS; CENPT and CENPW (CENP-T-W-S-X heterotetramer); involved in the formation of a functional kinetochore outer plate; which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes; binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428; PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS; with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).
- Gene Details:
- centromere protein X
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Centromere protein X protein (1-63AA)
- Isotype:
- IgG
- Protein Details:
- Centromere protein X
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
