SOCS1 Antibody
Product Sizes
50ug
£305.00
OACA03704-50UG
100ug
£463.00
OACA03704-100UG
About this Product
- SKU:
- OACA03704
- Additional Names:
- AISIMD;CIS1;CISH1;cytokine-inducible SH2 protein 1;JAB;JAK binding protein;JAK-binding protein;SOCS-1;SSI1;SSI-1;STAT induced SH3 protein 1;STAT-induced STAT inhibitor 1;suppressor of cytokine signaling 1;Tec-interacting protein 3;TIP3;TIP-3.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs; inhibits their kinase activity. In vitro; also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
- Gene Details:
- suppressor of cytokine signaling 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)
- Isotype:
- IgG
- Protein Details:
- Suppressor of cytokine signaling 1
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
