LAIR1 Antibody
Product Sizes
50ug
£305.00
OACA03217-50UG
100ug
£463.00
OACA03217-100UG
About this Product
- SKU:
- OACA03217
- Additional Names:
- CD305;immunoglobulin heavy chain variable region;LAIR-1;leukocyte-associated Ig-like receptor 1;leukocyte-associated immunoglobulin-like receptor 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells; B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells; down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8; IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
- Gene Details:
- leukocyte associated immunoglobulin like receptor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)
- Isotype:
- IgG
- Protein Details:
- Leukocyte-associated immunoglobulin-like receptor 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
