IPO13 Antibody
Product Sizes
50ug
£305.00
OACA03163-50UG
100ug
£463.00
OACA03163-100UG
About this Product
- SKU:
- OACA03163
- Additional Names:
- IMP13;importin-13;KAP13;karyopherin 13;Karyopherin-13;late gestation lung 2;LGL2;Ran binding protein 13;ran-binding protein 13;RANBP13.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring; Ran-dependent mechanism. At the nucleoplasmic side of the NPC; Ran binds to the importin; the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9; the RBM8A/MAGOH complex; PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A; and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
- Gene Details:
- importin 13
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Importin-13 protein (501-700AA)
- Isotype:
- IgG
- Protein Details:
- Importin-13
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
