IFIT5 Antibody
Product Sizes
50ug
£305.00
OACA03133-50UG
100ug
£463.00
OACA03133-100UG
About this Product
- SKU:
- OACA03133
- Additional Names:
- IFIT-5;interferon-induced 58 kDa protein;interferon-induced protein with tetratricopeptide repeats 5;ISG58;P58;retinoic acid- and interferon-inducible 58 kDa protein;retinoic acid- and interferon-inducible protein (58kD);RI58.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- Varies by lot. See vial for exact concentration.
- Extra Details:
- Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312; PubMed:23317505; PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA); thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs; which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead; are specific from viruses; providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally; as a mediator in innate immunity; regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).
- Gene Details:
- interferon induced protein with tetratricopeptide repeats 5
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
- Isotype:
- IgG
- Protein Details:
- Interferon-induced protein with tetratricopeptide repeats 5
- Purity:
- > 95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
