HNRNPA2B1 Antibody
Product Sizes
50ug
£305.00
OACA03110-50UG
100ug
£463.00
OACA03110-100UG
About this Product
- SKU:
- OACA03110
- Additional Names:
- epididymis secretory sperm binding protein;heterogeneous nuclear ribonucleoproteins A2/B1;hnRNP A2 / hnRNP B1;HNRNPA2;HNRNPA2B1/MYC fusion;HNRNPB1;HNRPA2;HNRPA2B1;HNRPB1;IBMPFD2;nuclear ribonucleoprotein particle A2 protein;RNPA2;SNRPB1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs; packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription; pre-mRNA processing; RNA nuclear export; subcellular location; mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs; and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences; protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules; such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation; possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing; possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
- Gene Details:
- heterogeneous nuclear ribonucleoprotein A2/B1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 protein (1-249AA)
- Isotype:
- IgG
- Protein Details:
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
