FFAR3 Antibody
Product Sizes
50ug
£305.00
OACA02966-50UG
100ug
£463.00
OACA02966-100UG
About this Product
- SKU:
- OACA02966
- Additional Names:
- FFA3R;free fatty acid receptor 3;GPR41;GPR42;G-protein coupled receptor 41.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- G protein-coupled receptor that is activated by a major product of dietary fiber digestion; the short chain fatty acids (SCFAs); and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals; the short chain fatty acids acetate; propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive; G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1;4;5-trisphosphate; the mobilization of intracellular calcium; the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate; a ketone body produced by the liver upon starvation; it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein; phospholipase C and MAP kinases. Thereby; it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine; it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance; regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility; intestinal transit rate; and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin; a hormone acting on the CNS to inhibit food intake; in response to the presence of short-chain fatty acids in the intestine. Finally; may also play a role in glucose homeostasis. Besides its role in energy homeostasis; may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut; regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs; the fatty acids containing less than 6 carbons; the most potent activators are probably propionate; butyrate and pentanoate while acetate is a poor activator (PubMed:12496283; PubMed:12711604).
- Gene Details:
- free fatty acid receptor 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Free fatty acid receptor 3 protein (280-346AA)
- Isotype:
- IgG
- Protein Details:
- Free fatty acid receptor 3
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
