DNA2 Antibody
Product Sizes
50ug
£305.00
OACA02862-50UG
100ug
£463.00
OACA02862-100UG
About this Product
- SKU:
- OACA02862
- Additional Names:
- DNA replication ATP-dependent helicase/nuclease DNA2;DNA replication ATP-dependent helicase-like homolog;DNA replication helicase 2 homolog;DNA2 DNA replication helicase 2-like;DNA2L;DNA2-like helicase;hDNA2.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA); leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA; while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities; such as single-stranded DNA (ssDNA)-dependent ATPase; 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair; the 5'-3' DNA helicase activity is subject to debate. According to various reports; the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap; helping the nuclease function.
- Gene Details:
- DNA replication helicase/nuclease 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
- Isotype:
- IgG
- Protein Details:
- DNA replication ATP-dependent helicase/nuclease DNA2
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
