ATXN3 Antibody
Product Sizes
50ug
£305.00
OACA02633-50UG
100ug
£463.00
OACA02633-100UG
About this Product
- SKU:
- OACA02633
- Additional Names:
- AT3;ataxin-3;ATX3;JOS;josephin;Machado-Joseph disease protein 1;MJD;MJD1;olivopontocerebellar ataxia 3;SCA3;spinocerebellar ataxia type 3 protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Deubiquitinating enzyme involved in protein homeostasis maintenance; transcription; cytoskeleton regulation; myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501; PubMed:17696782; PubMed:23625928; PubMed:28445460; PubMed:16118278). Binds long polyubiquitin chains and trims them; while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP; and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).
- Gene Details:
- ataxin 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ataxin-3 protein (1-288AA)
- Isotype:
- IgG
- Protein Details:
- Ataxin-3
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
