CCL5 Antibody - FITC Conjugated
Product Sizes
100ug
£478.00
OACA01281-100UG
About this Product
- SKU:
- OACA01281
- Additional Names:
- beta-chemokine RANTES;C-C motif chemokine 5;chemokine (C-C motif) ligand 5;D17S136E;eoCP;eosinophil chemotactic cytokine;RANTES;regulated upon activation; normally T-expressed; and presumably secreted;SCYA5;SISd;SIS-delta;small inducible cytokine subfamily A (Cys-Cys); member 5;Small-inducible cytokine A5;T cell-specific protein P228;T-cell specific protein p288;T-cell-specific protein RANTES;TCP228.
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- Chemoattractant for blood monocytes; memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1; CCR3; CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1; HIV-2; and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620; PubMed:1380064; PubMed:8525373; PubMed:9516414; PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75; stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75; may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3; Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
- Gene Details:
- C-C motif chemokine ligand 5
- Host:
- Rabbit
- Immunogen:
- Recombinant Human C-C motif chemokine 5 protein (24-91AA)
- Isotype:
- IgG
- Protein Details:
- C-C motif chemokine 5
- Purity:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
