RAB10 Antibody - FITC Conjugated
Product Sizes
100ug
£478.00
OACA00773-100UG
About this Product
- SKU:
- OACA00773
- Additional Names:
- GTP-binding protein RAB10;ras-related GTP-binding protein;ras-related protein Rab-10.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- The small GTPases Rab are key regulators of intracellular membrane trafficking; from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation; movement; tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates; for instance; SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel; it regulates the transport of TLR4; a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons; it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells; it regulates transport from the Golgi to the basolateral membrane. Moreover; may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280; may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.
- Gene Details:
- RAB10; member RAS oncogene family
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ras-related protein Rab-10 protein (1-196AA)
- Isotype:
- IgG
- Protein Details:
- Ras-related protein Rab-10
- Purity:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
