PHF5A Antibody - Biotin Conjugated
Product Sizes
100ug
£478.00
OACA00738-100UG
About this Product
- SKU:
- OACA00738
- Additional Names:
- bK223H9.2;INI;PHD finger-like domain protein 5A;PHD finger-like domain-containing protein 5A;PHD-finger 5a;Rds3;SAP14b;SF3b14b;SF3B7;splicing factor 3B associated 14 kDa protein;splicing factor 3b; subunit 7;Splicing factor 3B-associated 14 kDa protein.
- Clonality:
- Polyclonal
- Conjugate:
- Biotin
- Extra Details:
- Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II; and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci; and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications; including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3); on PAF1C targets; self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes; and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643; PubMed:28541300). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential; it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity).
- Gene Details:
- PHD finger protein 5A
- Host:
- Rabbit
- Immunogen:
- Recombinant Human PHD finger-like domain-containing protein 5A protein (1-110AA)
- Isotype:
- IgG
- Protein Details:
- PHD finger-like domain-containing protein 5A
- Purity:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
