EIF4EBP2 Antibody - HRP Conjugated
Product Sizes
100ug
£478.00
OACA00391-100UG
About this Product
- SKU:
- OACA00391
- Additional Names:
- 4EBP2;4E-BP2;eIF4E-binding protein 2;eukaryotic translation initiation factor 4E-binding protein 2;PHASII;phosphorylated; heat and acid stable regulated by insulin protein II.
- Clonality:
- Polyclonal
- Conjugate:
- HRP
- Extra Details:
- Repressor of translation initiation involved in synaptic plasticity; learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E; leading to repress translation. In contrast; hyperphosphorylated form dissociates from EIF4E; allowing interaction between EIF4G1/EIF4G3 and EIF4E; leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones; growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
- Gene Details:
- eukaryotic translation initiation factor 4E binding protein 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2 protein (1-120AA)
- Isotype:
- IgG
- Protein Details:
- Eukaryotic translation initiation factor 4E-binding protein 2
- Purity:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
