EFNA1 Antibody - FITC Conjugated
Product Sizes
100ug
£478.00
OACA00380-100UG
About this Product
- SKU:
- OACA00380
- Additional Names:
- B61;EPH-related receptor tyrosine kinase ligand 1;ephrin-A1;immediate early response protein B61;LERK-1.
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- Cell surface GPI-bound ligand for Eph receptors; a family of receptor tyrosine kinases which are crucial for migration; repulsion and adhesion during neuronal; vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells; leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2; VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
- Gene Details:
- ephrin A1
- Host:
- Rabbit
- Immunogen:
- Recombinant Rat Ephrin-A1 protein (18-182AA)
- Isotype:
- IgG
- Protein Details:
- Ephrin-A1
- Purity:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
