CASP8 Antibody
Product Sizes
100ul
£597.00
OABF01693-100UL
About this Product
- SKU:
- OABF01693
- Additional Names:
- ALPS2B;apoptotic cysteine protease;apoptotic protease Mch-5;CAP4;Casp-8;caspase 8; apoptosis-related cysteine peptidase;caspase 8; apoptosis-related cysteine protease;caspase-8;FADD-homologous ICE/CED-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MACH;MACH-alpha-1/2/3 protein;MACH-beta-1/2/3/4 protein;MCH5;MORT1-associated ced-3 homolog.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3; CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3; CASP4; CASP6; CASP7; CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate; Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5; isoform 6; isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
- Gene Details:
- caspase 8
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human Caspase-8 subunit p18
- Isotype:
- IgG
- Protein Details:
- Caspase-8
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
