MAPK7 Antibody
Product Sizes
100ul
£597.00
OABF01574-100UL
About this Product
- SKU:
- OABF01574
- Additional Names:
- big MAP kinase 1;BMK1;BMK-1;BMK1 kinase;ERK4;ERK5;ERK-5;Extracellular signal-regulated kinase 5;extracellular-signal-regulated kinase 5;MAP kinase 7;MAPK 7;mitogen-activated protein kinase 7;PRKM7.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Plays a role in various cellular processes such as proliferation; differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation; it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
- Gene Details:
- mitogen-activated protein kinase 7
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation sites of Ser731+Thr733
- Isotype:
- IgG
- Protein Details:
- Mitogen-activated protein kinase 7
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
