FGFR1 Antibody
Product Sizes
100ul
£597.00
OABF01554-100UL
About this Product
- SKU:
- OABF01554
- Additional Names:
- bacteria-expressed kinase;basic fibroblast growth factor receptor 1;BBDS;BEK;BEK fibroblast growth factor receptor;BFGFR;bFGF-R-1;BFR-1;CD331;CD332;CEK;CEK3;CFD1;ECCL;ECT1;FGFBR;FGFR-1;FGFR1/PLAG1 fusion;fibroblast growth factor receptor 1;fibroblast growth factor receptor 2;FLG;FLT2;FLT-2;FMS-like tyrosine kinase 2;fms-related tyrosine kinase 2;HBGFR;heparin-binding growth factor receptor;HH2;HRTFDS;hydroxyaryl-protein kinase;JWS;KAL2;keratinocyte growth factor receptor;KGFR;K-SAM;N-SAM;OGD;protein tyrosine kinase; receptor like 14;proto-oncogene c-Fgr;TK14;TK25.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg); FGFR-2 (bek; KGFR); FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain; a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization; the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463; Tyr583; Tyr585; Tyr653; Tyr654; Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
- Gene Details:
- fibroblast growth factor receptor 1|fibroblast growth factor receptor 2
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr463
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
