AKT1 Antibody
Product Sizes
100ul
£597.00
OABF01535-100UL
About this Product
- SKU:
- OABF01535
- Additional Names:
- AKT;AKT1m;HIHGHH;MPPH;MPPH2;murine thymoma viral (v-akt) homolog-2;PKB;PKB alpha;PKB beta;PKB gamma;PKB-ALPHA;PKBB;PKBBETA;PKBG;PKB-GAMMA;PRKBA;PRKBB;PRKBG;protein kinase Akt-2;protein kinase B alpha;protein kinase B beta;proto-oncogene c-Akt;putative v-akt murine thymoma viral oncoprotein 2;RAC;rac protein kinase alpha;rac protein kinase beta;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-BETA;RAC-beta serine/threonine-protein kinase;RAC-gamma;RAC-gamma serine/threonine protein kinase;RAC-gamma serine/threonine-protein kinase;RAC-PK-alpha;RAC-PK-beta;RAC-PK-gamma;serine-threonine protein kinase;STK-2;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene homolog 2;v-akt murine thymoma viral oncogene homolog 3 (protein kinase B; gamma);v-akt murine thymoma viral oncogene-like protein 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- AKT; also known as protein kinase B (PKB); is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha); AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain; a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8; and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors; cytokines and insulin). PI3 kinase recruits AKT to the membrane; where it is activated by PDK1 phosphorylation. Once phosphorylated; AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.
- Gene Details:
- AKT serine/threonine kinase 1|AKT serine/threonine kinase 2|AKT serine/threonine kinase 3
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Tyr315
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
