LPAR1 Antibody
Product Sizes
100ul
£597.00
OABF01103-100UL
About this Product
- SKU:
- OABF01103
- Additional Names:
- edg-2;EDG2;endothelial differentiation; lysophosphatidic acid G-protein-coupled receptor; 2;Gpcr26;LPA receptor 1;LPA1;LPA-1;lysophosphatidic acid receptor 1;lysophosphatidic acid receptor Edg-2;Mrec1.3;rec.1.3;ventricular zone gene 1;vzg-1;VZG1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Receptor for lysophosphatidic acid (LPA) (PubMed:9070858; PubMed:19306925; PubMed:25025571; PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton; cell migration; differentiation and proliferation; and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o); G(12)/G(13); and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035; PubMed:19733258; PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1;4;5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor; plays a role in chemotaxis and cell migration; including responses to injury and wounding (PubMed:18066075; PubMed:19656035; PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation; survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
- Gene Details:
- lysophosphatidic acid receptor 1
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human EDG2/LPAR1
- Isotype:
- IgG
- Protein Details:
- Lysophosphatidic acid receptor 1
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
