MDC1 Antibody
Product Sizes
100ul
£597.00
OABF00959-100UL
About this Product
- SKU:
- OABF00959
- Additional Names:
- homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint protein 1;NFBD1;nuclear factor with BRCT domains 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM; CHEK1 and CHEK2 kinases; and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
- Gene Details:
- mediator of DNA damage checkpoint 1
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human MDC1
- Isotype:
- IgG
- Protein Details:
- Mediator of DNA damage checkpoint protein 1
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
