PCNA Antibody
Product Sizes
100ul
£261.00
OABF00281-100UL
About this Product
- SKU:
- OABF00281
- Additional Names:
- ATLD2;cyclin;DNA polymerase delta auxiliary protein;proliferating cell nuclear antigen.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Concentration:
- 1 ug/ul
- Extra Details:
- Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase; but not apurinic-apyrimidinic (AP) endonuclease; APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases; while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- Gene Details:
- proliferating cell nuclear antigen
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human PCNA
- Isotype:
- IgG
- Protein Details:
- Proliferating cell nuclear antigen
- Purification:
- Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
