Human MAP2K3 Antibody : PE
Product Sizes
10 Tests
£218.00
OAAQ00146-10TESTS
100 Tests
£457.00
OAAQ00146-100TESTS
About this Product
- SKU:
- OAAQ00146
- Additional Names:
- MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
- translate.label.attr.clone:
- MKK3S189MKK6S207-D3
- Clonality:
- Monoclonal
- Conjugate:
- PE: Phycoerythrin
- Extra Details:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress; and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin; and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase; which thus leads to the constitutive activation of MAPK14; and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
- Gene Details:
- mitogen-activated protein kinase kinase 3
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Ser189 of human phospho MKK3 and Ser207 of human phospho MKK6.
- Isotype:
- Rabbit IgG1k
- Protein Details:
- dual specificity mitogen-activated protein kinase kinase 3
- Purification:
- Protein A+G
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
