CAMK2B Antibody
Product Sizes
50ul
£264.00
OAAN03304-50UL
100ul
£379.00
OAAN03304-100UL
200ul
£581.00
OAAN03304-200UL
About this Product
- SKU:
- OAAN03304
- Additional Names:
- CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta
- Clonality:
- Polyclonal
- Extra Details:
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation; and is involved in dendritic spine and synapse formation; neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons; plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A; which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons; promotes arborization of the dendritic tree and in mature neurons; promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles; is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin; a ryanodine receptor-coupling factor; and phospholamban (PLN/PLB); an endogenous inhibitor of SERCA2A/ATP2A2.
- Gene Details:
- calcium/calmodulin dependent protein kinase II beta
- Host:
- Rabbit
- Immunogen:
- Recombinant Protein
- Isotype:
- IgG
- Molecular Weight:
- 73 kDa
- Protein Details:
- Interleukin enhancer-binding factor 3
- Purification:
- Affinity purification
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquote and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
