DISC1 Antibody
Product Sizes
50ul
£312.00
OAAN00981-50UL
100ul
£451.00
OAAN00981-100UL
200ul
£718.00
OAAN00981-200UL
About this Product
- SKU:
- OAAN00981
- Additional Names:
- C1orf136;disrupted in schizophrenia 1 protein;SCZD9.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis; including neuron positioning; dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role; together with PCNT; in the microtubule network formation.
- Gene Details:
- DISC1 scaffold protein
- Host:
- Rabbit
- Immunogen:
- DISC1
- Isotype:
- IgG
- Molecular Weight:
- 94kDa
- Protein Details:
- Disrupted in schizophrenia 1 protein
- Purification:
- Affinity purified against immunogen
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
